ROMANCE: RObust Metabolomics Analyses with Normalized CE.

date added
01 October 2018
1288 times

Please contact us if you are interested in the source code.

If you use this software for your research, please cite us:

  • Victor González-Ruiz, Yoric Gagnebin, Nicolas Drouin, Santiago Codesido, Serge Rudaz, Julie Schappler. “ROMANCE”: a new software tool to improve data robustness and feature identification in CE-MS metabolomics. Electrophoresis, 2018, DOI: 10.1002/elps.201700427.
  • Santiago Codesido, Nicolas Drouin, Sabrina Ferre, Julie Schappler, Serge Rudaz, Víctor González-Ruiz. A mature ROMANCE: a matter of quantity and how two can be better than one. ChemRxiv preprint, 2020, DOI: 10.26434/chemrxiv.12287048.v1
  • Software available online at

ROMANCE v2.0 (English)

ROMANCE is multi-platform and can run on any operating system. However, the latest version of the Java Runtime Environment is required (min JRE 8).

Download (5.41 Mo) Manual

ROMANCE can automatically convert batches of CE-MS files from the time scale into the electrophoretic mobility scale. It works with the new standard mzML format for MS data, so it can be transparently incorporated into any existing data treatment workflow. The software accepts MS(/MS) data in both centroid or profile format. The software can convert data by using the separation voltage, capillary length and m/z of a marker peak. Such marker can be either a neutral molecule (EOF marker, electrophoretic mobility = 0) or a known mobility compound. The converted files are written in the electrophoretic mobility scale, thus correcting most of the experimental sources of variation and making possible intra- and inter-laboratory comparison and data exchange, provided that the same BGE is used.