CROSSING BIOLOGICAL BARRIERS






Active substances


Small molecules, peptides and antibodies

Formulation


Nanoparticles, microparticles, semi solids, film and patch

Innovative technologies


Laser ablation / Iontophoresis

Quantification of active substance


HPLC-UV / UPLC-MS/MS

Prodrug design


Synthesis and characterization

Visualization


Electron Microscopies

NEWS FEED



April 2021

Prof. Kalia and Dr. Lapteva were invited speakers at the “Quality & Equivalence of Topical Products & Nanotechnology Challenges” hybrid workshop (https://labhnn.com/workshop/) organised by Dr. Nathalie Hasler-Nguyen of Labhnn.

Prof. Kalia’s talk was entitled “Cutaneous Biodistribution: A New Tool for Formulation Development and the Assessment of Bioequivalence of Topical Dermatological Products” and Dr. Lapteva’s talk was entitled “Opportunities of Nanotechnology for Topical Dermal Medicines”.


March 2021

The following papers was published


February 2021

The following paper, first-authored by Dr. Neeraj Thakur, was published:


January 2021

Jan 20: PhD Thesis defense

  • Investigating the Cutaneous Spatial Biodistribution of Pharmaceutical Molecules after Topical Application: from the Design of Polymeric Micelle Formulations to the Development of Quantitative and Qualitative Techniques
    Julie Quartier

Jan 14: PhD Thesis defense

  • Adapting a Naturally Occurring Protein Cage to Modulate an Array of Therapeutic Delivery Properties in Various Disease Settings.
    Whitney Shatz

The following papers were published

  • Iontosomes: Electroresponsive Liposomes for Topical Iontophoretic Delivery of Chemotherapeutics to the Buccal Mucosa. Sonaje K, Tyagi V, Chen Y, Kalia YN.
    Pharmaceutics. 2021 Jan 11;13(1):88. doi: 10.3390/pharmaceutics13010088
  • Using protease inhibitors to improve protein stability in the presence of skin: A case study on the stability of insulin like growth factor 1. Dubey S, Perozzo R, Scapozza L, Kalia YN.
    Eur J Pharm Biopharm. 2021 Jan;158:379-381. doi: 10.1016/j.ejpb.2020.12.009

November 2020

We welcomed Benjamin Rossier as a new PhD student in the group – his project is jointly supervised by Prof. Kalia and Prof. Eric Allémann.

The following papers was published

  • Specific protein-protein interactions limit the cutaneous iontophoretic transport of interferon beta-1b and a poly-Arg interferon beta-1b analogue. Dubey S, Perozzo R, Scapozza L, Kalia YN.
    Int J Pharm. 2020 Nov 15;589:119913. doi: 10.1016/j.ijpharm.2020.119913

September 2020

We welcomed Dr. Neeraj Thakur as a new postdoctoral scientist in the group.

The following papers was published

  • Using Ex Vivo Porcine Jejunum to Identify Membrane Transporter Substrates: A Screening Tool for Early-Stage Drug Development. Arnold YE, Kalia YN.
    Biomedicines. 2020 Sep 10;8(9):340. doi: 10.3390/biomedicines8090340

June 2020

The following papers was published

  • Tissue Levels of Flurbiprofen in the Rat Plantar Heel after Short-Duration Topical Iontophoresis are Sufficient to Induce Pharmacodynamic Responses to Local Pain Stimuli. Cai Y, Zhou Y, Zhang P, Kalia YN, Gratieri T, Chen Y.
    Pharmaceutics. 2020 Jun 30;12(7):608. doi: 10.3390/pharmaceutics12070608

May 2020

May 8: PhD Thesis defense

  • Microparticle, Nanocarrier and Fractional Laser Ablation:vFormulation and Physical Enhancement Strategies to Increase Cutaneous and Ungual drug Bioavailability
    Si Gou

April 2020

The following papers were published

  • Targeted cutaneous delivery of etanercept using Er:YAG fractional laser ablation. Del Río-Sancho S, Lapteva M, Sonaje K, Böhler C, Ling V, Boehncke WH, Kalia YN.
    Int J Pharm. 2020 Apr 30;580:119234. doi: 10.1016/j.ijpharm.2020.119234
  • Non-invasive targeted iontophoretic delivery of cetuximab to skin. Lapteva M, Sallam MA, Goyon A, Guillarme D, Veuthey JL, Kalia YN.
    Expert Opin Drug Deliv. 2020 Apr;17(4):589-602. doi: 10.1080/17425247.2020.1731470

December 2019

The following papers were accepted for publication

  • Ocular Biodistribution of Spironolactone after a Single Intravitreal Injection of a Biodegradable Sustained-Release Polymer in Rats.
    Dahmana N, Kowalczuk L, Gabriel D, Behar-Cohen F, Gurny R, Kalia YN.
    Mol Pharm. 2019 Dec 5. doi: 10.1021/acs.molpharmaceut.9b00707
  • Ferritin as a natural protein scaffold: Building a multivalent ferritin-Fab conjugate.
    Shatz W, Blanchette C, Holder P, Kelley RF, Perozzo R, Kalia YN.
    LC-GC. 2019; 37 Suppl 11 (Advances in Biopharmaceutical Analysis): 30-35.

November 2019

Nov 22: PhD Thesis defense

  • Advanced drug delivery systems to enhance topical oromucosal administration of therapeutic agents.
    Vasundhara Tyagi

September 2019

The following papers were accepted for publication

  • Cutaneous Biodistribution: A High-Resolution Methodology to Assess Bioequivalence in Topical Skin Delivery.
    Quartier J, Capony N, Lapteva M, Kalia YN.
    Pharmaceutics. 2019 Sep 18;11(9). pii: E484. doi: 10.3390/pharmaceutics11090484.

We had three communications at the Skin and Formulation 5th Symposium & 17th Skin Forum, September 23-24, 2019, Reims, France.

  • In vitro assessment of bioequivalence of topical products for dermatological indications.
    J. Quartier, N. Capony, M. Lapteva, Y. N. Kalia.
  • Polymeric micelle formulations for the cutaneous delivery of sirolimus: a new approach for the treatment of facial angiofibromas in tuberous sclerosis.
    J. Quartier, M. Lapteva, Y. N. Kalia. (Prize for best oral presentation)
  • Influence of copolymer concentration and nature on tacrolimus-loaded micelles: evaluation of formulation characteristics and cutaneous drug delivery.
    J. Quartier, M. Lapteva, Y. N. Kalia.

August 2019

We welcomed Dr. Maryam Dabbaghi from the Translational Research Center, Diamantina Institute, Faculty of Medicine, University of Queensland as a visiting student in the group.

The following papers were accepted for publication

  • Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters.
    Daneluti ALM, Neto FM, Ruscinc N, Lopes I, Robles Velasco MV, Do Rosário Matos J, Baby AR, Kalia YN.
    Int J Pharm. 2019 Aug 19;570:118633. doi: 10.1016/j.ijpharm.2019.118633
  • Topical iontophoresis of buflomedil hydrochloride increases drug bioavailability in the mucosa: A targeted approach to treat oral submucous fibrosis.
    Tyagi V, Sancho SD, Lapteva M, Kalia YN.
    Int J Pharm. 2019 Aug 12:118610. doi: 10.1016/j.ijpharm.2019.118610

July 2019

The following paper was accepted for publication:

  • Controlled Iontophoretic Delivery in Vitro and in Vivo of ARN14140-A Multitarget Compound for Alzheimer's Disease.
    Singhal M, Merino V, Rosini M, Cavalli A, Kalia YN.
    Mol Pharm. 2019 Aug 5;16(8):3460-3468. doi: 10.1021/acs.molpharmaceut.9b00252

We had six communications at the Controlled Release Society Annual Meeting and Exposition, July 21-24, 2019, Valencia, Spain

Investigation of the segmental activity of the MRP3 drug transporter in porcine intestine ex vivo.
Y. Arnold, Y. N. Kalia.

A micelle-based triple antifungal formulation for topical treatment of fungal infections.
S. Gou, M. Monod, D. Salomon, Y. N. Kalia.

Novel methodology to assess bioequivalence of topical products for dermatological indications.
M. Lapteva, N. Capony, J. Quartier, Y. N. Kalia.

Non-invasive iontophoretic delivery of cytochrome c to the posterior segment and determination of its ocular biodistribution.
S. Messaoudi, L. Gonzalez-Iglesias, Y. N. Kalia.

Polymeric micelle formulations for the cutaneous delivery of tacrolimus: influence of copolymer concentration and nature.
J. Quartier, M. Lapteva, Y. N. Kalia.

Fractional laser ablation for the targeted topical delivery of infliximab from cryomilled polymeric microparticles.
P. F. Sahraoui, M. Singhal, Y. N. Kalia.


May 2019

The following paper was accepted for publication:

  • Er:YAG fractional laser ablation for cutaneous co-delivery of pentoxifylline and d-α-tocopherol succinate: A new approach for topical treatment of radiation-induced skin fibrosis.
    Gou S, Del Rio-Sancho S, Singhal M, Laubach HJ, Kalia YN.
    Eur J Pharm Sci. 2019 Jul 1;135:22-31. doi: 10.1016/j.ejps.2019.05.007.

We had communications at the 21st Annual European Pharma Congress. May 20-22, 2019, Zürich, Switzerland:

Ferritin-antibody fragment conjugates: protein scaffolds to modify physicochemical and pharmacokinetic properties of biotherapeutics.
W. Shatz, C. Blanchette, R. F. Kelley, R. Perozzo, Y. N. Kalia

and the 21st Transporter and Barrier Meeting. May 27-29, 2019, Bad Herrenalb, Karlsruhe, Germany:

Investigation of apical drug transporter activity using ex vivo porcine intestine to facilitate identification of potential drug-drug-interactions at an early state of drug development.
Y. E. Arnold, Y. N. Kalia


April 2019

We welcomed Ms. Laeticia Pinto as a new PhD student in the group

The following paper was accepted for publication

  • Polymeric micelle nanocarriers for targeted epidermal delivery of the hedgehog pathway inhibitor vismodegib: formulation development and cutaneous biodistribution in human skin.
    Kandekar SG, Singhal M, Sonaje KB, Kalia YN.
    Expert Opin Drug Deliv. 2019 Apr 17. doi: 10.1080/17425247.2019.

March 2019

The following paper was accepted for publication

  • Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption.
    Arnold YE, Thorens J, Bernard S, Kalia YN.
    Pharmaceutics. 2019 Mar 21;11(3). pii: E139. doi: 10.3390/pharmaceutics11030139.

We had a communication at the 3rd European Conference on Pharmaceutics – Bringing science into pharmaceutical practice. March 25-26, 2019, Bologna, Italy.

Investigation of drug transporter activity in ex vivo porcine intestinal mucosa
Y. E. Arnold, Y. N. Kalia.


February 2019

We welcomed Ms. Phedra Firdaws Sahraoui as a new PhD student in the group.


January 2019

The following paper was accepted for publication

  • Fractional laser ablation for the targeted cutaneous delivery of an anti-CD29 monoclonal antibody - OS2966.
    Lapteva M, Del Río-Sancho S, Wu E, Carbonell WS, Böhler C, Kalia YN.
    Sci Rep. 2019 Jan 31;9(1):1030. doi: 10.1038/s41598-018-36966-0.
  • Self-assembled mPEG-hexPLA polymeric nanocarriers for the targeted cutaneous delivery of imiquimod.
    Lapteva M, Mignot M, Mondon K, Möller M, Gurny R, Kalia YN.
    Eur J Pharm Biopharm. 2019 Jan 12. pii: S0939-6411(18)31203-7. doi: 10.1016/j.ejpb.2019.01.008.
    [Epub ahead of print]

December 2018

Dec 7: PhD Thesis defense

  • Nanocarrier systems and iontophoresis: Complementary approaches for targeted cutaneous delivery of hydrophobic and hydrophilic drugs.
    Somnath Kandekar

The following paper was accepted for publication

  • Investigation of Different Iontophoretic Currents Profiles for Short-Term Applications in Cosmetics.
    Cázares-Delgadillo J, Planard-Luong L, Gregoire S, Serna-Jiménez CE, Singhal M, Kalia YN, Merino V, Merino-Sanjuán M, Nácher A, Martínez-Gómez MA, Burnier-Yalaoui V, Barbarat P.
    Pharmaceutics. 2018 Dec 7;10(4). pii: E266. doi: 10.3390/pharmaceutics10040266.

November 2018

The following paper was accepted for publication

  • Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases.
    Shatz W, Aaronson J, Yohe S, Kelley RF, Kalia YN.
    Expert Opin Drug Deliv. 2018 Nov 29. doi: 10.1080/17425247.2019.1553953

September 2018

We welcomed Mr. Fernando Sà, a visiting PhD student from the Laboratory of Food, Drug and Cosmetics, University of Brasilia, to the group.


The following paper was accepted for publication

  • Controlled non-invasive iontophoretic delivery of triamcinolone acetonide amino acid ester prodrugs into the posterior segment of the eye.
    Santer V, Chen Y, Kalia YN.
    Eur J Pharm Biopharm. 2018 Nov;132:157-167. doi: 10.1016/j.ejpb.2018.09.020. Epub 2018 Sep 25.

August 2018

We had two communication at the 12th International Conference and Workshop on Biobarriers, August 27-29, 2018, Saarbrücken, Germany.

  • Development and biopharmaceutical evaluation of sirolimus-loaded micelles for targeted cutaneous delivery.
    J. Quartier, M. Lapteva, Y. N. Kalia.
  • Investigation into the use of organ preservation solutions to extend viability of porcine intestinal tissue for use in drug absorption studies.
    J. Quartier, Y. E. Arnold, Y. N. Kalia.

July 2018

The following paper has been published from our group:

  • Hyaluronic Acid After Subcutaneous Injection-An Objective Assessment.
    Santer V, Molliard SG, Micheels P, Río-Sancho SD, Quinodoz P, Kalia YN, Salomon D.
    Dermatol Surg. 2018 Jul 9. doi: 10.1097/DSS.0000000000001609. [Epub ahead of print]

We also had a communication at the 18th European Congress on Biotechnology, July 1-4, 2018, Geneva, Switzerland.

  • Targeted cutaneous delivery of an anti-CD29 mAb for the topical treatment of psoriasis.
    M. Lapteva, S. del Río Sancho, E. Wu, W. S. Carbonell, C. Böhler, Y. N. Kalia

Prof. Kalia was a speaker at the Proteins & Peptides: Structure, Function & Biotechnology Meeting, July 23-26, 2018, Geneva, Switzerland.

  • Needle-less delivery of peptides and proteins into and across the skin: Creating new therapeutic opportunities

June 2018

June 22: PhD Thesis defense

  • Targeted delivery of spironolactone for the treatment of cutaneous and ocular diseases involving mineralocorticoid receptor over-activation.
    Naoual Dahmana

We had a communication at Phytopharm 2018 (22nd Annual Meeting), June 25-27, 2018, Horgen and ZHAW Wädenswil, Switzerland

  • Investigation of the absorption and metabolism of Pueraria lobata extract constituents with a porcine small intestine ex vivo model.
    J. Houriet, Y. E. Arnold, C. Petit, Y. N. Kalia, J.-L. Wolfender.

May 2018

The following papers have been published from our group:

  • Development and validation of a fast and sensitive UHPLC-ESI-MS method for the simultaneous quantification of spironolactone and its metabolites in ocular tissues.
    Dahmana N, Gabriel D, Gurny R, Kalia YN.
    Biomed Chromatogr. 2018 May 16:e4287. doi: 10.1002/bmc.4287. [Epub ahead of print]
  • Needle-free cutaneous delivery of living human cells by Er:YAG fractional laser ablation.
    Yu J, Dubey S, Kalia YN.
    Expert Opin Drug Deliv. 2018 Jun;15(6):559-566. doi: 10.1080/17425247.2018.1472570. Epub 2018 May 23.

We also had a communication at the EUFEPS Annual meeting, May 24-26, 2018, Athens, Greece.

  • Development and evaluation of a triple antifungal micelle-based formulation for topical treatment of superficial fungal infections.
    S. Gou, M. Monod, D. Salomon, Y. N. Kalia.

April 2018

April 27: PhD Thesis defense

  • Development of new chemical and physical strategies to enhance topical drug delivery.
    Verena Santer

April 11: PhD Thesis defense

  • Physical techniques to overcome the cutaneous barrier: how iontophoresis and fractional laser ablation change the delivery kinetics of drugs
    Mayank Singhal

March 2018

We welcomed Mr. Jonathan Faros Barros as a new PhD student in the group.

We had several presentations at the 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 19-22, 2018, Granada, Spain.

  • Laser-assisted topical delivery of OS2966 for the treatment of psoriasis.
    M. Lapteva, S. del Río Sancho, E. Wu, W. S. Carbonell, C. Böhler, Y. N. Kalia.
  • Spironolactone micelles for the management of cutaneous wound healing.
    N. Dahmana, R. Gurny, Y. N. Kalia.
  • Topical delivery of spironolactone nanocarriers prevents dexamethasone-induced delayed corneal wound healing.
    N. Dahmana, T. Mugnier, D. Gabriel, V. Kaltsatos, T. Bertaim, Francine Behar-Cohen, R. Gurny, Y. N. Kalia.
  • Improved cutaneous delivery of pentoxifylline using P. L. E. A. S. E. ® fractional laser ablation.
    S. Gou, S. Rio-Sancho, M. Singhal, H.-J. Laubach, Y. N. Kalia.
  • Buccal iontophoretic delivery of buflomedil hydrochloride for oral submucous fibrosis.
    V. Tyagi, S. del Rio-Sancho, M. Singhal, H.-J. Laubach, Y. N. Kalia.
  • Ex vivo porcine small intestine to investigate passive drug absorption.
    Y. E. Arnold, J. Thorens, S. Bernard, Y. N. Kalia.
  • Laser-assisted transdermal delivery of paroxetine hydrochloride from a microemulsion formulation.
    L. G. González-Iglesias, C. Serna-Jiménez, A. Ganem-Rondero, Y. N. Kalia.

February 2018

We welcomed Mr. Aditya Darade as a new PhD student in our group.

The following papers were published from our group:

  • Simultaneous controlled iontophoretic delivery of pramipexole and rasagiline in vitro and in vivo: Transdermal polypharmacy to treat Parkinson's Disease.
    Kalaria DR, Singhal M, Patravale V, Merino V, Kalia YN.
    Eur J Pharm Biopharm. 2018 Feb 22. pii: S0939-6411(17)31365-6. doi: 10.1016/j.ejpb.2018.02.031. [Epub ahead of print]
  • Topical administration of spironolactone-loaded nanomicelles prevents glucocorticoid-induced delayed corneal wound healing in rabbits.
    Dahmana N, Mugnier T, Gabriel D, Kaltsatos V, Bertaim T, Behar-Cohen F, Gurny R, Kalia YN.
    Mol Pharm. 2018 Mar 5;15(3):1192-1202. doi: 10.1021/acs.molpharmaceut.7b01028. Epub 2018 Feb 15.

January 2018

The following papers have been published from our group:

  • Selective delivery of adapalene to the human hair follicle under finite dose conditions using polymeric micelle nanocarriers.
    Kandekar SG, Del Río-Sancho S, Lapteva M, Kalia YN.
    Nanoscale. 2018 Jan 18;10(3):1099-1110. doi: 10.1039/c7nr07706h.
  • Short-duration ocular iontophoresis of ionizable aciclovir prodrugs: A new approach to treat herpes simplex infections in the anterior and posterior segments of the eye.
    Chen Y, Kalia YN.
    Int J Pharm. 2018 Jan 30;536(1):292-300. doi: 10.1016/j.ijpharm.2017.11.069. Epub 2017 Dec 2.

We also had an abstract at Phytovalley, January 14-16, 2018, Seefeld, Austria.

  • Anti-obesity effects of Puerariae lobatae radix: moving towards a rational investigation of the mechanism of action.
    J. Houriet, E. Buhlmann, C. Rudigier, Y. E. Arnold, E. Kiehlmann, J. Radtke, T. Friedemann, Y. N. Kalia, S. Schröder, C. Wolfrum, J.-L. Wolfender.