Welcome to the Molecular Pharmacology Group
at the Institute of Pharmaceutical Sciences of Western Switzerland
The overall aim of the Molecular Pharmacology Group’s research is the identification of optimized therapeutic strategies for the treatment of complex disease, mainly cancer. Our optimization strategy uses fundamental research to reveal the action mechanisms of the optimized drug mixtures. The latter, in turn, may identify novel signaling pathways, mechanisms of resistance and may lead to new drug discovery alleys.
The mainstays of the ongoing research are:
- design of personalized optimization of multidrug combinations
- identification of novel targets for treatment
- patient-derived 3D in vitro tumor models
- cell fate mechanisms
- overcoming acquired resistance of targeted drugs
- alternative to mammalian screening models
We work in a close collaboration with clinicians, engineers, biologists and medical oncologists in order to perform clinically relevant translational research to improve cancer treatment efficacy, reduce side effects and probability of a drug acquired resistance. Our ultimate goal is to develop personalized synergistic combination therapies to the dynamically changing tumor response.
- Magdalena Rausch presents her PhD project in a Booster Prize competition
- Our research gains attention of specialists - see beyond the abstract release: https://www.urotoday.com/recent-abstracts/urologic-oncology/renal-cancer/122174-identification-of-low-dose-multidrug-combinations-for-sunitinib-naive-and-pre-treated-renal-cell-carcinoma-beyond-the-abstract.html
- Our lab in a full workforce after the shutdown - great feeling again!
- Magdalena Rausch gives a talk during the lnternactional Conference of Molecular, Cell and Cancer Biology 2020
- Our study on drug-drug interactions in chemotherapeutic cocktails is now available: https://www.mdpi.com/1420-3049/25/11/2614
- Check the movie created by Sahar Boss, Arbenita Dervishaj and Camille Paccard on colorectal cancer: https://ispso.unige.ch/labs/NOWAK/files/15_vulgarisation.mp4
- George M. Ramzy published his first paper in our lab. Congratulations! https://www.mdpi.com/2072-6694/12/6/1423
- Interview of Prof E. Allemann and Prof. P. Nowak-Sliwinska published in the Swiss news journal 24 heures (23 May 2020): Cellules dé cvag et placenta pour réduir es tests sur l'animal. Zoom sur les alternatives à l'expérimentation in vivo, entre atouts et limites
- Prof. Patrycja Nowak-Sliwinska awarded with the 3R UNIGE 2020 prize.
- Marloes Zoetemelk defended her PhD thesis on 28th of February 2020. Congratulations!
- Prof. Patrycja Nowak-Sliwinska and Prof. Patrick Meraldi in an interview for Radio Television Swiss:https://www.rts.ch/la-1ere/programmes/cqfd/11118908-une-nouvelle-strategie-contre-les-cellules-cancereuses-10-03-2020.html?mediaShare=1