Biomedical and metabolomics analysis
Innovation in Instrumentation and Analytical Strategies
Capillary electrophoresis and coupling to sensors for biomedical analysis and characterization of counterfeit drug
Miniaturized sample preparation techniques for the extraction of polar compounds
- Simultaneous approach qual/quant as: development of the multiple injection
- CE and MS (/ MS): evaluation of new coupling interfaces
- CE and fluorescence: investigation of new bypass reactive
- • CE and electrochemistry: coupling to the conductivity measurements and amperometric titration
Miniaturized sample preparation techniques for the extraction of polar compounds
- liquid micro-extractions: EME, DLLME
- solid micro-extractions online SPE μSPE
- Handling of atypical biological fluids: cerebrospinal fluid, cell cultures, seminal fluid
BIOMEDICAL, TOXICOLOGICAL AND METABOLOMIC ANALYSIS
In vitro, in vivo toxicity studies
Neurotoxicity
Neurotoxicity
- Cellular models (2D and 3D)
- Polar compounds analysis
- Serum, plasma, urine, seminal fluid analysis (>150 compounds)
- Endocrine disruption (H295R)
- Steroidogenesis evaluation
- Environmental exposure (dioxin)
- Targeted/untargeted acquisition in CE and LC-MS(/MS)
- Normalization strategies
- Retention time modeling
- Database
- Cellular models (HLM)
- Xenobiotics
- Phase I and II biotransformations
Methodology and Data Analysis
Experimental design
Multivariate analysis
Advanced methods
- Factor screening
- Response surface for process optimization
- Accuracy and uncertainty profiles
- Quality by design
Multivariate analysis
- Dimensionality reduction
- Knowledge extraction
- Machine learning
Advanced methods
- Multiblock analysis
- Multiway analysis
- Megavariate analysis of variance
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