Biomedical and metabolomics analysis
Innovation in Instrumentation and Analytical Strategies
Capillary electrophoresis and coupling to sensors for biomedical analysis and characterization of counterfeit drug
- Simultaneous approach qual/quant as: development of the multiple injection
- CE and MS (/ MS): evaluation of new coupling interfaces
- CE and fluorescence: investigation of new bypass reactive
- • CE and electrochemistry: coupling to the conductivity measurements and amperometric titration
Miniaturized sample preparation techniques for the extraction of polar compounds
- liquid micro-extractions: EME, DLLME
- solid micro-extractions online SPE μSPE
- Handling of atypical biological fluids: cerebrospinal fluid, cell cultures, seminal fluid
BIOMEDICAL, TOXICOLOGICAL AND METABOLOMIC ANALYSIS
In vitro, in vivo toxicity studies
Neurotoxicity
- Cellular models (2D and 3D)
- Polar compounds analysis
Extended steroid profile
- Serum, plasma, urine, seminal fluid analysis (>150 compounds)
- Endocrine disruption (H295R)
- Steroidogenesis evaluation
- Environmental exposure (dioxin)
Metabolomics analysis
- Targeted/untargeted acquisition in CE and LC-MS(/MS)
- Normalization strategies
- Retention time modeling
- Database
Metabolism study
- Cellular models (HLM)
- Xenobiotics
- Phase I and II biotransformations
Methodology and Data Analysis
Experimental design
- Factor screening
- Response surface for process optimization
Validation of analytical methods
- Accuracy and uncertainty profiles
- Quality by design
Development and application of chemometric tools for metabolomics
Multivariate analysis
- Dimensionality reduction
- Knowledge extraction
- Machine learning
Clustering / Regression / Discriminant analysis / Classification
Advanced methods
- Multiblock analysis
- Multiway analysis
- Megavariate analysis of variance