Our overall aim is to develop novel treatments to enhance the body's immune defenses against cancer.
We are currently working on the following questions:
You can find more detailed information on the ongoing projects in "Research section"
The Warhol Nanoparticles
These images depict the uptake of nanoparticles into immune cells. More and more nanoparticles are used as delivery vehicles to bring specific immune-activating drugs directly to immune cells, thereby increasing their efficacy. Thus, it is important to evaluate their potent uptake into these cells beforehand. Here, I chose the same image in different color schemes to convey a sense of the diversity of these promising new delivery agents.
Finding arts in science. The immunofluorescence image of cultured murine colorectal carcinoma cells. The labelling is for focal adhesion kinase (FAK) in green, red for β-actin (cytoskeleton), and yellow/orange for colocalization of FAK and β-actin. The nucleus is DAPI stained, blue. (Created with BioRender.com).
Finding arts in science
Monsters & Co. (Gastric tumors)
Detail of early development of gastric tumors in a mouse model of stomach cancer stained with the technique of multicolour-immunofluorescence. The green color indicates tumor cells in the pathogenic state of hypoxia, which are rapidly growing as indicated by the red color in the nuclei. Immune cells colored in magenta surround the tumors.
Betül Taskoparan, Julia Wagner & Viola Puddinu
Congratulations to Betül Taskoparan for winning Best Poster First Prize & Best Poster Layout Prize during 16th Spring School of Immunology organized by German Society of Immunology, October 25-30, 2020, Ettal (Germany).
Congratulations to Dr. Viola Puddinu for her promotion to Research and Teaching Fellow, November 1, 2020.
Congratulations to our 3 PhD students Julia Wagner, Betül Taskoparan and Hélène Poinot for winning a Registration Grant for the 14th World Immune Regulations Meeting (WIRM-XIV), October 4-7, 2020, Davos (Switzerland)
Congratulations to Julia Wagner for the Poster Prize of the 14th World Immune Regulations Meeting (WIRM-XIV), "Combination of a TLR agonist with a STING ligand induces T cell death", October 4-7, 2020, Davos (Switzerland).
The 3rd prize "ISPSO Master" for the best personal research work was awarded to Jérémie Tachet for his work entitled "Impact of glucocorticoid metabolism on anticancer immunity" carried out in our lab. Congratulations !
Congratulations to Dr. Aurélien Pommier for receiving a grant from the Swiss Innovation Agency Innosuisse, to support the next 18 months work of the team on the discovery of novel immunotherapy treatment for patients with renal cancer.
Congratulations to Dr. Viola Puddinu for being awarded a grant from the Novartis Foundation for one year to study the connection between stomach cancer and the gastric microbiota.
We are welcoming Guillaume Disner who is starting his PhD in our lab on January 1, 2021.
We are welcoming Jérémie Tachet who is starting his PhD in our lab on January 1, 2021.